IDH1 and acute myeloid leukemia: Over the past decades, several gene mutations, such as CEBPA, NPM1, FLT3-ITD, C-KIT, DNMT3A, and IDH1/2, and changes in gene expression, such as overexpression of BAALC, ERG, EVI1, and MN1, have been discovered to strongly affect clinical outcome of CN-AML patients [4].