Similarly, the secondary analysis of the GeparTrio trial [35] showed that even if the IBC and LABC groups combined (12.2%) had a lower pCR rate than patients with OBC (23.6%), the difference was not significant in multivariate analysis, suggesting that tumor stage itself was not an independent predictor of pCR and that the different pCR rates observed were likely due to heterogeneity in tumor features such as grade or hormone receptor status. This evidence concerns the gene NR4A1 and neoplasm.