To determine whether the effect of FZD7 on cell migration and invasion was associated with EMT, expressions of several epithelial markers (β-catenin and E-cadherin) and mesenchymal markers (Vimentin, Fibronectin and N-cadherin) were compared between FZD7- overexpression/repression ESCC cells and their control cells by IF analysis and Western blot. The gene discussed is FN1; the disease is esophageal squamous cell carcinoma.