By univariable analysis, overexpression of FZD7 (P=0.001), poor differentiation (P=0.001), presence of lymph node (LN) metastasis (P=0.001) and advanced TNM stage (P<0.0001) were significant negative prognostic factors for overall survival in ESCC patients (Table 1). This evidence concerns the gene FZD7 and esophageal squamous cell carcinoma.