PPP3R1 and neoplasm: Studies have also shown that overexpression of CNB can significantly increase TNF-α/CHX-induced apoptosis, which may be achieved by affecting the function of mitochondria [19], and exogenous CNB rapidly enters cells through TLR4 receptors and induces the secretion of cytokines, but have certain cytotoxicity in some TLR4-rich tumor cells [20].