PSEN1 and Alzheimer disease: Although our current study did not investigate the effects of running exercise on Aβ deposition in the white matter of APP/PS1 AD mice, our team previously investigated this issue; we found Aβ plaque deposition in the white matter of 10-month-old APP/PS1 AD mice, but running exercise had no effect on Aβ plaque deposition in the white matter of APP/PS1 AD mice [13].