TUG1 and cholangiocarcinoma: In addition, the majority of cell lines showed substantially higher levels of TUG1 expression compared to HIBEC cells, indicating that TUG1 might be involved in tumorigenesis and progression of CCA (Huh28, p=0.038; KMBC, p=0.033; HuCCT1, p=0.003; QBC939, p<0.001; RBE, p<0.001; Figure 1B).