Finally, the following factors were included in the best risk prediction models: a history of breastfeeding, a history of benign breast disease, CT+TT at TOX3-rs3803662, CT+TT at ESR1-rs2046210, GG at 8q24-rs13281615, and TT at SLC4A7-rs4973768 for premenopausal women with an AUC of 0.762 (Table 5 and Figure 2A), and BMI, a history of breastfeeding, hyperlipidemia, serum testosterone levels, serum 25-hydroxyvitamin D levels, TT at TOX3-rs3803662, and CT+TT at ESR1-rs2046210 for postmenopausal women with an AUC of 0.757 (Table 5 and Figure 2B). The gene discussed is TOX3; the disease is breast fibrocystic disease.