Na+/H+ Exchanger Regulatory Factor1/ezrin-radixin-moesin (ERM) binding phosphoprotein of 50 KDa (NHERF1/EBP50), which is a scaffold multifunctional protein, binds ERM proteins through its C-terminal ezrin-binding domain, a large variety of other proteins via its two tandem PDZ (postsynaptic density 95/disc-large/zona) domains, and many cancer-related proteins [3-6]. The gene discussed is NHERF1; the disease is cancer.