Indeed, when comparing CLL B cells to memory B cells, differences were related to the IGHV UM CLL group for DNMT1 (P = 0.0025) and TET2 (P = 0.04); and to the IGHV M CLL group for MBD4 (P = 0.03). The gene discussed is DNMT1; the disease is B-cell chronic lymphocytic leukemia.