CD5 and B-cell chronic lymphocytic leukemia: Peripheral blood total B cells, peripheral blood B cell subsets (naïve, memory), CD5+ B1a cells from umbilical cord blood, peripheral blood or tonsil and CD5 transfected B cell lines have been used in order to uncover CLL specific modifications [15, 16, 43].This key point may explain, in part, the conflicting results reported in CLL when exploring DNMT [26, 27] and TET expression [19, 50].