And a research revealed that miR-129-2 might serve as a prognostic indicator for HCC patients and exerted a tumor suppressive role by inhibiting high mobility group box 1 (HMGB1) [24].What’s more, miR-324-3p has been suggested to be involved in tumorigenesis and tumor development by acting as an oncogene or tumor suppressor in several cancers, such as nasopharyngeal carcinoma [9, 25], colorectal cancer [26] and lung squamous cell carcinoma [10]. The gene discussed is HMGB1; the disease is cancer.