TUG1 and esophageal squamous cell carcinoma: Interestingly, previous studies have shown that TUG1 were up-regulated in BRC [7], CRC [8], OC [9], SCLC [10], OSA [18], GC [19], ESCC [16], ccRCC [6, 20], BC [15] and MIBC [17], and function as an oncogene, while TUG1 were down-regulated in NSCLC [11, 12], glioma [13] as well as UC [14], and function as a tumor suppressor.