MYC and esophageal squamous cell carcinoma: The results showed that knockdown of c-MYC significantly sensitized Eca109 and Kyse150 ESCC cells to CDDP (Figure 5E, 5F, and Supplementary Figure 4), while Ec9706 cells with constitutive c-MYC overexpression exhibited significantly superior cell viability (Supplementary Figure 5E and Supplementary Figure 4) and less apoptosis (Figure 5F) after CDDP treatment.