The overexpression of cellular myelocytomatosis oncogene (C-MYC; a downstream target of STAT3) integrated with the overexpression of B-cell lymphoma 2 (BCL-2) in DLBCL has been shown to influence the prognosis and predict the therapeutic response in patients receiving chemotherapy [7, 8]. Here, STAT3 is linked to diffuse large B-cell lymphoma.