A previous study showed that SOX7 might be a negative regulator of Wnt/β-catenin signaling pathway through disrupting the transcriptional activity of β-catenin–TCF/LEF complex and its downstream targets, such as Cyclin D1, c-Myc, and FGF9 in endometrial cancer [18]. The gene discussed is HNF4A; the disease is endometrial cancer.