Notably, 20% (74/367) of the discordant cases (loss of PTEN protein expression by IHC and normal PTEN by FISH analysis) showed heterogeneous PTEN protein loss in some, but not all, sampled tumor glands, compared to only 11% (121/1087) of cases with PTEN IHC loss overall which showed heterogeneous PTEN loss. The gene discussed is PTEN; the disease is neoplasm.