Here, using different cancer transplantation models in mice, we report that the ANP-GC-A pathway suppresses pre-metastatic niche formation in the lung of BALB/c females bearing 4T1 breast cancer and of C57BL/6 males bearing Lewis Lung Carcinoma (LLC), suggesting a general role for ANP in metastasis inhibition. Here, NPPA is linked to Carcinoma, Lewis Lung.