IGF2 and carcinoma: Notably, miR483 maps at 11p15.5 within the second intron of the insulin-like growth factor 2 (IGF2) gene [7], which is one of the most hyper-expressed genes in ACC [7, 8, 19], and is involved, although apparently not being sufficient in promoting ACC in the mouse [20, 21], in the multistep progression process underlying the carcinoma development [22].