SPC24 and lung carcinoma: In light of the discovery, future studies should be directed to (1) interrogate the mechanism by which SPC24 stimulates development of lung cancer; (2) reveal how SPC24 promotes EMT and metastasis; (3) validate SPC24 as a prognostic marker of lung cancer in clinical cohorts; and (4) test if other components of the spindle checkpoint machinery will confer similar functions as what has been observed for SPC24.