PHB1 and cancer: As a consequence, high levels of prohibitin expression have been demonstrated in several transformed cells and in many primary human cancers, including endometrial adenocarcinoma [28], hepatocellular carcinoma [29], gastric cancer [30], esophageal cancer [31], bladder cancer [32], and breast cancer [33], however their role in hematologic malignancies and tumorigenic mechanisms of action have not been fully elucidated.