Similar to prohibitin localization in normal PBMCs [36] and Kit225 cells (Figure 2), PHB1 and PHB2 co-localize primarily to peri-nuclear regions with a specific punctuate staining pattern, indicative of mitochondrial localization, in T-ALL (Figure 6A) and CML (Figure 6B). This evidence concerns the gene PHB2 and chronic myelogenous leukemia, BCR-ABL1 positive.