n346077, which encodes a 2609bp transcript and located in the opposite strand of mitochondrial ribosomal protein L23 (MRPL23) gene on chromosome 11, is one of the down-regulated lncRNAs, to probe the potential role of it in HCC cells, we first performed MTT, colony formation, cell migration, and invasiveness assays in HepG2 and QGY-7703 cells with n346077 overexpression. This evidence concerns the gene MRPL23 and hepatocellular carcinoma.