Among them, the lncRNAs highly up-regulated in liver cancer (HULC), high expression in HCC (HEIH), HBx-interspersed nuclear element 1 (HBx-LINE1), H19, HOTAIR, Unigene56159, down-regulated expression by HBx (DREH) and microvascular invasion in HCC (MVIH) are strongly implicated in the development of HBV-related HCC [14–21]. This evidence concerns the gene HOTAIR and hepatocellular carcinoma.