The ISH studies performed with 85 paraffin-embedded HCC specimens from Cohort 2 confirmed the up-regulation of lncRNA UBE2CP3 in HCC and suggested that lncRNA UBE2CP3 was localized to the cytoplasm of HCC tissue (P < 0.001; Figure 1C and 1D).These findings indicate that lncRNA UBE2CP3 is frequently up-regulated in HCC. This evidence concerns the gene UBE2CP3 and hepatocellular carcinoma.