TNF and breast cancer: In the last years, BC risk has been linked to the smoking, to the occupational exposures [4], to the use of drugs like cyclophosphamide or chlornaphazine [5], to the environmental pollutants and the arsenicals [6, 7], and to the chronic inflammation with the related up-regulation of some pro-inflammatory proteins like interleukin (IL)-6, tumor necrosis factor (TNF) and C-reactive protein (CRP) [8].