TET2 and malignant colon neoplasm: In our study, compared with the normal tissue expression of TET2 in AML decreased or absent, suggesting that its expression is closely related with the occurrence of AML, we observed that TET2 in AML this law in the process of change was confirmed in the experimental study of Yang [31] people, they found that TET protein expression decreased in the family liver cancer and colon cancer, breast cancer.