Our study will analyze AML in TET2 inactivation and MEG3relationship, and further explore the relationship between TET2 and miR-22-3p/5p, the latter will continue to study MEG3, TET2, the relationship between miR-22-3p/5p, to determine the molecular mechanism of MEG3 inactivation. This evidence concerns the gene MEG3 and acute myeloid leukemia.