High DISC1 expression was correlated with smoking status (P=0.049), tumor size (P=0.013), pathology grade (P<0.001), grade (P=0.020), lymph node metastasis (P=0.032), and Ki-67 (P<0.001), p-GSK3β (P<0.001), β-catenin (P<0.001), and Cyclin D1 expression (P<0.001) (Table 1). This evidence concerns the gene GSK3B and metastatic malignant neoplasm in the lymph nodes.