Our most recently published study indicated CD44 regulated glucose metabolism, intracellular reactive oxygen species(ROS), and cell proliferation in PC3 cells.[6] 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) is required for balancing glycolytic activity and antioxidant production in prostate cancer cells [7]. Here, CD44 is linked to Familial prostate cancer.