GNRH1 and cancer: Research studies have recently demonstrated that berberine had widely anti-tumor activity, its action mechanism containing inhibit the proliferation and induce the apoptosis of cancer cell, inhibit the invasion and migration of cancer cell, anti-cancer angiogenesis, and it is induced by regulate LHRH and VEGF receptors activate, and it has potential pharmacological activity in the treatment of prostate cancer, but the action of mechanism is unclear, thus its development and application on treating prostate cancer has been always limited [37–39].