The results demonstrated that phospho-Lyn level was gradually reduced in the F/P(+) CEL cases and EOL-1 cells with phospho-F/P inhibited by imatinib (Figure 1), which suggested Lyn kinase is the target of F/P oncoprotein. The gene discussed is LYN; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.