The six lines evaluated expressed varying level of SOX7 transcript (Figure 2B) and protein (Figure 2C); MV4;11 an AML line used as a negative control did not expressed SOX7. To modulate SOX7 expression, we tested several shRNAs against SOX7 transcripts (Figure 2D), all of which induced greater than 95% decrease in SOX7 transcript levels in the endothelial HUVEC cells expressing high level of the SOX7 transcripts (Figure 2E). The gene discussed is SOX7; the disease is acute myeloid leukemia.