CNR2 and Alzheimer disease: Either AD-MSCs or CB2 agonist alone significantly lowered the MI-induced increase of O 2- generation(versus the PBS group, P < 0.05, Figure 3A, 3B, 3C), while combined treatment of AD-MSCs and CB2 agonist further decsssreased O 2- generation (P < 0.05, Figure 3A, 3B, 3C).