In addition to its involvement in the pathogenesis of cancer, a genome-wide methylation screening using human fibrotic kidney fibroblasts and experimental renal fibrosis models identified that RASAL1 was hypermethylated via Dnmt1 after TGF-β stimulation in renal fibrosis, with substantial suppression of RASAL1 expression [11]. The gene discussed is DNMT1; the disease is renal fibrosis.