MAPT and Alzheimer disease: Accordingly, passive immunization with different tau antibodies directed against the extreme and mid-region in N-terminal end of protein turns out to be the most beneficial in reducing pathological tau hyperphosphorylation and in improving cognition of aged (16-months-old) 3XTg AD mice [20], thus fostering the targeting of these selective epitopes as an actual opportunity for the cure of AD and other tauopathies.