RAP2B and breast cancer: Additionally, we demonstrated that Rap2B promoted migration and invasion of human breast cancer and suprarenal epithelioma [7, 14].Significantly, Mestre et al. have reported that Rap2b along with cAMP, EPAC, and calpain activation negatively regulate Hla-induced autophagy, indicating that Rap2B is involved in the autophagic pathway [15].