The univariate analysis showed the frequencies of allele rs14024-G of KRT1 were significantly increased in the SLE patients (57.62% vs 44.62%, OR: 1.69, 95%CI: 1.30–2.12, p = 6.48×10−5) and SSc (60.10% vs. 44.62%, OR: 1.87, 95%CI: 1.36–2.56, p = 8.75×10−5) against the normal controls (Table 1), while the frequencies of the deletion allele (S) at indel rs267607656 were significantly lower in SLE and SSc patients than that in normal healthy population (OR: 0.66, 95%CI: 0.49–0.89, p = 0.007 and OR: 0.49, 95%CI: 0.33–0.74, p = 4.89×10−4, respectively, Table 1). The gene discussed is KRT1; the disease is systemic lupus erythematosus.