The frequencies of the mutant haplotype (KRT1-MU, G-L) were significantly higher in SLE (57.62% vs. 44.62%, OR: 1.69, 95%CI: 1.30–2.19, p = 6.48×10−5) and SSc (60.1% vs. 44.62%, OR: 1.87, 95%CI: 1.36–2.56, p = 8.75×10−5) than that in the control (Table 3). The gene discussed is KRT1; the disease is systemic sclerosis.