IFIH1 is a double-strand RNA receptor and play a vital role in innate immune response during virus infection by inducing the expression of interferon.[38] Polymorphisms in IFIH1 were also shown association with Aicardi-Goutières syndrome [39], type 1 diabetes mellitus[40] and psoriasis[41]. The gene discussed is IFIH1; the disease is Aicardi-Goutieres syndrome.