XPO1 and infection: Previous studies have elucidated various sites in the trafficking itinerary of the Matrix protein as it has been shown to exit the nucleus through a Crm-1 mediated nuclear export mechanism [7] and subsequently localize late in infection to cytoplasmic inclusions with the N, P and M2-1 proteins [14], with G in the Golgi [22] and later with the F protein at the plasma membrane in lipid rafts [5].