The main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors; inverse of high-density lipoprotein (HDL-C), TG, BP, insulin resistance (HOMA-IR), waist circumference (WC) and inverse of cardiorespiratory fitness (CRF). The gene discussed is BDNF; the disease is Insulin resistance.