CASP3 and Miyoshi myopathy: To corroborate our hypothesis that BMP2 does not induce apoptosis in MM cells we therefore analysed whether BMP2 stimulation resulted in proteolytic activation of the initiator caspase-8 and effector caspase-3 employing Western blot analysis at 0 h, 24 h, 48 h and 72 h stimulation.