For this study we investigated a panel of novel neo-epitope ECM biomarkers; MMP3 and -9, degraded biglycan (BGM) [24], neutrophil elastase degraded elastin (EL-NE) [23], MMP-9 degraded type V collagen (C5M) [25], and type V pro-collagen (Pro-C5) [26] from different proteinase degradation products and their relation to IBD. This evidence concerns the gene ELANE and inflammatory bowel disease.