OCRL and oculocerebrorenal syndrome: Together, these data raise the possibility that loss of OCRL causes seizures in humans due to immune activation in the brain, by mechanisms similar to those we have uncovered in Drosophila. Thus, our finding that dOCRL acts specifically in hemocytes to restrain innate immune cell activation provides a novel line of inquiry into the pathogenesis of the symptoms in Lowe Syndrome patients.