In particular, KCC2 dysfunction contributes to the onset of seizures (Huberfeld et al., 2007; Kahle et al., 2014; Puskarjov et al., 2014; Stödberg et al., 2015; Saitsu et al., 2016), neuropathic pain (Coull et al., 2003), schizophrenia (Tao et al., 2012), and autism spectrum disorders (ASD) (Cellot and Cherubini, 2014; Tang et al., 2016a; Banerjee et al., 2016). The gene discussed is SLC12A5; the disease is autism spectrum disorder.