KCC2 dysregulation has emerged as a key mechanism underlying several brain disorders including seizures (Fiumelli et al., 2013; Stödberg et al., 2015; Saitsu et al., 2016), neuropathic pain (Coull et al., 2003), schizophrenia (Tao et al., 2012), and autism spectrum disorders (ASD) (Cellot and Cherubini, 2014; Tang et al., 2016a). The gene discussed is SLC12A5; the disease is autism spectrum disorder.