Here we showed that in adult males exposed to BPA, several DE epigenetic factors in our Epigenetics module (Figure 8) were upregulated, except sirt5, sirt2 and hdac5. This is interesting because this signature suggests that short term exposure to BPA also leads to the acquisition of cancer hallmark capabilities in directly exposed fish via a specific shift in chromatin configuration. This evidence concerns the gene HDAC5 and cancer.