SOD1 and amyotrophic lateral sclerosis: Although the polarization of M1/M2-like microglia during amyotrophic lateral sclerosis (ALS) may induce motoneuron degeneration or neuroprotection [66], isolated microglia from mutant superoxide dismutase 1-ALS mice revealed a microglial subpopulation between M1-like and M2-like phenotypes by transcriptome analysis [67].