SIRT1 and amyotrophic lateral sclerosis: Administration of a daily RSV-enriched diet (160 mg/kg RSV) significantly delayed the onset of amyotrophic lateral sclerosis (ALS) in a SOD1G93A mouse model, by improving spinal motoneuron function, extending survival through the activation of SIRT1 and AMPK and promoting mitochondrial biogenesis in the spinal cord [99].