PGP and malignant colon neoplasm: Lamellarin O inhibited (1) Pgp in human Pgp-overexpressing colon cancer cells reversing P-gp mediated doxorubicin resistance; (2) MRP1 in human MRP1-overexpressing ovarian carcinoma cells; and (3) BCRP in human mitoxantrone-resistant non-small cell lung cancer cell lines increasing intracellular mitoxantrone [163].