Overall, compared to subjects with adequate blood 25(OH)D levels (i.e., ≥30 ng/mL), there was a 2.6-fold (95% CI: 1.3–5.2) increased likelihood of AMD in 25(OH)D deficient subjects (i.e., <12 ng/mL), a 3.4-fold (95% CI: 1.1–10.9) increased likelihood in subjects carrying one risk allele for CFH Y402H and a 6.7-fold (95% CI: 1.6–28.2) increased likelihood in subjects carrying two risk alleles. The gene discussed is CFH; the disease is age-related macular degeneration.