Also, the positive effects of curcumin on lifespan and inhibition of oligodendrocyte apoptosis 1, 84 in a jimpymsd mouse [model of PMD with a point mutation 24], and on the locomotor phenotype, astrocytosis, microgliosis and lymphocyte infiltration in the milder overexpressed Plp1, PLP‐tg72/7218, may be related to the anti‐inflammatory, antioxidant properties of the substance. This evidence concerns the gene PLP1 and Pelizeaus-Merzbacher spectrum disorder.