Possible critiques of the DAT knock-down mice are the clearly too low DAT expression compared with unmedicated BD patients, which is approximately 80% of healthy subjects (Anand et al. 2011; Young and Dulcis 2015) and that this animal model mimics only BD mania and not depression (van Enkhuizen et al. 2015a). This evidence concerns the gene SLC6A3 and depressive symptom measurement.