Possible critiques of the DAT knock-down mice are the clearly too low DAT expression compared with unmedicated BD patients, which is approximately 80% of healthy subjects (Anand et al. 2011; Young and Dulcis 2015) and that this animal model mimics only BD mania and not depression (van Enkhuizen et al. 2015a). The gene discussed is SLC6A3; the disease is Behcet disease.