PNPLA6 and cancer: The favorable gene signature included the following metabolic genes: PLA2G2D, PLA2G4A, PLA2G4C, and PLD2 phospholipases, LPGAT1, PNPLA6, AGPAT1, and AGPAT4. This observation further supports previous cancer profiling studies that have established important structural and signaling roles for phospholipids in the pathogenesis and malignancy of cancer cells [25].