The analysis in biopsy-proven LN patients with active renal disease revealed elevated protein levels of CSF1, sIL15RA, sCD40, sCX3CL1, caspase 8, sIL18R1, bNGF, and GDNF compared to those without LN (Table 2c, Fig. 5). The gene discussed is CASP8; the disease is kidney disorder.