Moreover, we observed great sensitivity and specificity for proteins sIL15RA (AUC: 0.879, sensitivity: 100%, specificity: 64.3%), CSF1 (0.813, 84.6, 78.6), sIL18R1 (0.810, 84.6, 78.6), and bNGF (0.805, 69.2, 100) showing good discrimination between active and inactive renal disease in LN patient subgroup (Additional file 1: Figure S3c, Table S5c). The gene discussed is CSF1; the disease is lobular neoplasia.