Several potential risk factors for AED hypersensitivity were reported: previous history of AED-induced eruption [24], autoimmune diseases, treatment with corticosteroids, family history of SCARs [25], age below 12 years or above 64 associated with altered drug metabolism [8], head injury, surgery, genetic markers such as HLA-B*15:02 and HLA-A*31:01, and reactivation of HHV-6 and -7, EBV and CMV virus [26, 27]. This evidence concerns the gene HLA-B and autoimmune disease.