ABHD5 and posterior cortical atrophy: We knocked down ABHD5 in PC3 cells with shRNAs and observed that knockdown of ABHD5 had negligible effects on the expression of E-Cadherin and Snail (Supplementary Figure 2A) and on cell invasion (Supplementary Figure 2B), which suggests that p53 is required for activation of EMT in PCa cells by ABHD5 loss.